发明名称 Method for increasing expression of an exogenous sequence in t cells, a kit based thereon, a pharmaceutical composition comprising at least one co-stimulatory agent and an adenovirus vector comprising an exogenous sequence
摘要 Described herein are methods of expressing nucleic acids in T cells pre-exposed to a co-stimulatory signal and then transduced with adenoviral vectors. In some embodiments, the co-stimulation is provided by anti-CD3 and anti-CD28 antibodies and the adenoviral vector is pseudotyped for T-cell entry. The invention also relates to compositions for carrying out these methods, provided as kits or pharmaceutical compositions that can be used to treat diseases including immunological conditions and hematological malignancies.
申请公布号 IL202184(A) 申请公布日期 2013.06.27
申请号 IL20090202184 申请日期 2009.11.17
申请人 SANGAMO BIOSCIENCES INC. 发明人
分类号 C12N 主分类号 C12N
代理机构 代理人
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