发明名称 |
MUTANT G-CSF FUSION PROTEIN, AND PREPARATION AND USE THEREOF |
摘要 |
The present invention relates to a mutant G-CSF fusion protein. The mutant G-CSF fusion protein is a fusion protein having the activity of stimulating the proliferation of neutrophilic granulocytes, and having a basic structure of G-CSF/carrier protein or carrier protein/G-CSF; wherein the G-CSF moiety comprises multipoint substitutions thus resulting in changes in biological activity and binding affinity. Compared with existing products, the mutant G-CSF fusion protein in the present invention has longer half-life and higher biological activity. Administration of the pharmaceutical preparation containing this mutant G-CSF fusion protein could be used in the treating neutropenia.
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申请公布号 |
US2013164251(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
US201013575752 |
申请日期 |
2010.06.30 |
申请人 |
WEN XIAOFANG;WU YILIANG;WANG YEFEI;YANG ZHIYU;FAN MIN;WANG YUJIAO;FANG XIAOCHUN;LU YOU |
发明人 |
WEN XIAOFANG;WU YILIANG;WANG YEFEI;YANG ZHIYU;FAN MIN;WANG YUJIAO;FANG XIAOCHUN;LU YOU |
分类号 |
C07K14/535;C07K14/765 |
主分类号 |
C07K14/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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