METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY
摘要
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
申请公布号
WO2013096843(A1)
申请公布日期
2013.06.27
申请号
WO2012US71380
申请日期
2012.12.21
申请人
MYRIAD GENETICS, INC.;ABKEVICH, VICTOR;GUTIN, ALEXANDER;TIMMS, KIRSTEN;LANCHBURY, JERRY
发明人
ABKEVICH, VICTOR;GUTIN, ALEXANDER;TIMMS, KIRSTEN;LANCHBURY, JERRY