| 摘要 |
The present invention comprises aldimine-derived compounds, pharmaceutical compositions containing such compounds and pharmaceutically acceptable excipients, beside the use thereof for treating fungal infections of medicinal and/or veterinary importance. Aldimines and derivatives thereof have been shown to exhibit antifungal activity equivalent to or better than that of commercially available medicinal drugs, such as fluconazole. Since these drugs are new, pathogen resistance to these drugs is quite low. Aldimine synthesis is carried out in a single-step process in which the reaction is completed in two minutes, with yields of 70-98%, making large-scale production possible, since it is a fast and low-cost process, when compared to the production process of other pharmaceuticals available. |
| 申请人 |
UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG;FUNDACAO DE AMPARO A PESQUISA DE MINAS GERAIS - FAPEMIG;DE FATIMA, ANGELO;DE RESENDE, STOIANOFF;DE ASSIS SANTOS, DANIEL;APARECIDO SABINO, ADAO;BRONDI ALVEZ, ROSEMEIRE;MOREIRA DA SILVA, CLEITON;VIVIANE BUZANELLO MARTINS, CLEIDE;FURTADO FERREIRA MAGALHAES, THAIS;LETICIA DA SILVA, DANIELLE;KIILL GASPAROTO, ALAN |
发明人 |
DE FATIMA, ANGELO;DE RESENDE, STOIANOFF;DE ASSIS SANTOS, DANIEL;APARECIDO SABINO, ADAO;BRONDI ALVEZ, ROSEMEIRE;MOREIRA DA SILVA, CLEITON;VIVIANE BUZANELLO MARTINS, CLEIDE;FURTADO FERREIRA MAGALHAES, THAIS;LETICIA DA SILVA, DANIELLE;KIILL GASPAROTO, ALAN |
