发明名称 |
Bicyclic pyrazole compounds as allosteric modulators of mGluR5 receptors |
摘要 |
In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
AU2011338339(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
AU20110338339 |
申请日期 |
2011.12.07 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
CONN, P. JEFFREY;LINDSLEY, CRAIG W.;STAUFFER, SHAUN R.;JONES, CARRIE K.;CONDE-CEIDE, SUSANA;TONG, HAN MIN;BARTOLOME-NEBREDA, JOSE MANUEL;MACDONALD, GREGOR JAMES |
分类号 |
C07D231/54;A61K31/4162 |
主分类号 |
C07D231/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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