发明名称 |
Long-Term Storage of Non-Glycosylated Recombinant Human G-CSF |
摘要 |
The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbital is cooled to a temperature of -15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2° C. to 8° C. for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
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申请公布号 |
US2013164253(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
US201113805180 |
申请日期 |
2011.06.22 |
申请人 |
GRAUMANN KLAUS;LERCH HELMUT;LAUBER THOMAS;SANDOZ AG |
发明人 |
GRAUMANN KLAUS;LERCH HELMUT;LAUBER THOMAS |
分类号 |
C07K14/535 |
主分类号 |
C07K14/535 |
代理机构 |
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代理人 |
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地址 |
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