发明名称 |
THERAPEUTIC APPLICATIONS OF CALCIUM ELECTROPORATION TO EFFECTIVELY INDUCE TUMOR NECROSIS |
摘要 |
The present inventors have shown that electroporation with calcium ions are efficient on cutaneous and subcutaneous nodules. In particular the present inventors here disclose that a solution comprising calcium ions (Ca2+) with a concentration of at least 0.1 M is extremely useful in a method of treating a neoplasm, such as cancer with means for causing transient permeabilisation of the cell membranes of at least part of the neoplasm before, during and/or after administration of said solution,wherein said solution is administered with a ratio of 0.2 to 0.8 of the volume of said part of the neoplasm. |
申请公布号 |
WO2013091657(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
WO2012DK50496 |
申请日期 |
2012.12.21 |
申请人 |
HERLEV HOSPITAL;AARHUS UNIVERSITET |
发明人 |
GEHL, KAREN JULIE;FRANDSEN, STINE KROG;ERIKSEN, JENS OLE;HYLDKROG, HANNE MARGRETHE GISSEL;JENSEN, PERNILLE HOEJMAN |
分类号 |
A61K33/14;A61P35/00 |
主分类号 |
A61K33/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|