| 摘要 |
PURPOSE: A DNA aptamer which specifically binds itself to a breast cancer-related Her2(ERBB2) receptor is provided to effectively suppress metastasis and to diagnose cancer. CONSTITUTION: An ERBB2 aptamer specifically binds itself to ERBB2 and has a base of sequence number 7. The ERBB2 aptamer additionally contains a sequence of sequence number 39 or 40 linked to 5' end and a sequence of sequence number 41 or 42 linked to 3' end. A pharmaceutical composition for treating cancer contains the ERBB2 aptamer as an active ingredient. The cancer includes breast cancer, colon cancer, lung cancer, gallbladder cancer, pancreatic cancer, or gastric cancer. A composition for diagnosing cancer contains the ERBB2 aptamer as an active ingredient. |
