| 摘要 |
A compound of formula I or II or a salt, hydrate or solvate thereof: wherein R1 is hydrogen or a substituent; Y is sulfur or NRb where Rb is hydrogen or (1-3C)alkyl; ring A is either (i) an optionally substituted 5-membered heteroaryl ring comprising a nitrogen atom and one or more heteroatoms selected from nitrogen, oxygen and sulfur, or (ii) an optionally substituted 5-membered heteroaryl ring; L is a chain linker or is absent; ring B is optionally substituted and is selected from (4-7C)cycloalkyl, heteroaryl, heterocyclyl and aryl. Preferably, Y is sulfur, ring A is selected from 1,3-thiazolyl, 1,3-oxazolyl and pyridyl, L is either absent or is N(Me)C(O)- and ring B is selected from optionally substituted phenyl and substituted pyridyl. The compounds of formula I or II inhibit PIM (Proviral Integration site for the Moloney murine leukemia virus) kinase and may be useful in the treatment and/or prevention of proliferative disorders, such as cancer. |
