The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
申请公布号
EP2605787(A2)
申请公布日期
2013.06.26
申请号
EP20110763772
申请日期
2011.08.17
申请人
WYETH LLC
发明人
BERASI, STEPHEN PETER;BROWN, CHRISTOPHER TODD;CAIN, MICHAEL JOHN;CALABRO, VALERIE PERRINE;JUO, ZONG SEAN;MARTINEZ, ROBERT VINCENT PAUL;SEEHERMAN, HOWARD JOEL;WOZNEY, JOHN MARTIN