发明名称 |
SHIP1 MODULATORS AND RELATED METHODS |
摘要 |
Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed. |
申请公布号 |
EP2605767(A1) |
申请公布日期 |
2013.06.26 |
申请号 |
EP20110818895 |
申请日期 |
2011.08.22 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
WANG, XIAOXIA;MEIMETIS, LABROS, GEORGE;NODWELL, MATTHEW, BRUCE;ANDERSEN, RAYMOND |
分类号 |
A61K31/045;A61P35/00;C07C37/50;C07C67/08;C07C249/08;C07D223/32 |
主分类号 |
A61K31/045 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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