发明名称 |
Molecular clones with mutated HIV GAG/POL, SIV GAG and SIV ENV genes |
摘要 |
<p>Nucleic acid constructs containing HIV-1 gag / pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.</p> |
申请公布号 |
EP2128256(B1) |
申请公布日期 |
2013.06.26 |
申请号 |
EP20090010047 |
申请日期 |
2000.12.22 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PAVLAKIS, GEORGE |
分类号 |
C12N15/09;C12N15/11;A61K31/7088;A61K39/00;A61K39/21;A61K48/00;A61P31/18;C07K14/155;C07K14/16;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/22;C12N7/00;C12N15/63;C12N15/86;C12N15/867 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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