发明名称 |
Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis |
摘要 |
<p>Methods and compositions for restoring sensitivity to the antitumorigenic effects of antiestrogen therapy and/or cytotoxic therapy and inducing cell apoptosis are provided. Contacting tumor cells to GP88 antagonists (e.g., anti-GP88 antibodies, anti-GP88 antisense nucleic acids, GP88 siRNA, and small molecules) induces apoptosis and restores sensitivity to the antitumorigenic effects of antiestrogen therapy and cytotoxic therapy.
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申请公布号 |
EP1849480(A3) |
申请公布日期 |
2013.06.26 |
申请号 |
EP20070075019 |
申请日期 |
2004.06.23 |
申请人 |
A & G PHARMACEUTICAL, INC. |
发明人 |
SERRERO, GINETTE |
分类号 |
A61K39/395;A01N33/02;A61K;A61K31/00;A61K31/135;A61K31/56;A61K31/7088;A61K45/06;A61P35/00;C07K16/22;C07K16/28;C12N15/11 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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