Pyridinone and pyrimidinone derivatives as factor XIa inhibitors

摘要

Compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof: wherein Y is N or C(R5); Cyc1, Cyc2 and Cyc3 are C3-8cycloalkyl, 5-10-membered heterocycloalkyl, C5-10­aryl or 5-10-membered heteroaryl; R2 and R3 are hydrogen or substituents or R2 and R3 may be taken together to form C2-8alkylene, or R3 and R4 may be taken together to form C2-8alkylene wherein one carbon of the alkylene chain may be replaced by oxygen or sulphur (for example so as to form a dihydropyrrolo[1,2-a]pyrimidin-4(6H)-one or a 5-oxo-1,2,3,5-tetrahydro-3-indolizinyl group together with the adjacent ring); R4 and R5 are hydrogen or substituents; , R6 and R7 are substituents with R6 preferably being a 1H-tetrazol-1-yl group; and m, s and n are all 0-6; may be useful as inhibitors of Factor XIa. These compounds may be useful in the prevention of and/or therapy for thromboembolic diseases including stroke, myocardial infarction, atherosclerosis, deep vein thrombosis, arterial embolism or pulmonary embolism.