发明名称 ELUTION OF PROTEINS FROM HYDROXYAPATITE RESINS WITHOUT RESIN DETERIORATION
摘要 Proteins, including monoclonal antibodies, that have been retained on hydroxyapatite resins for purposes of protein separation, purification, or both, are eluted from the resins by a elution buffer that contains controlled amounts of calcium and phosphate ions. The buffer allows elution to be performed in repeated runs at an acidic pH without deterioration of the resin.
申请公布号 EP2606059(A2) 申请公布日期 2013.06.26
申请号 EP20110818724 申请日期 2011.08.17
申请人 BIO-RAD LABORATORIES, INC. 发明人 CUMMINGS, LARRY J.
分类号 C07K1/20;B01D15/42 主分类号 C07K1/20
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