发明名称 |
METHOD FOR ENHANCING FUNCTION OF T CELL |
摘要 |
Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases. |
申请公布号 |
EP2404997(A4) |
申请公布日期 |
2013.06.26 |
申请号 |
EP20100748842 |
申请日期 |
2010.03.05 |
申请人 |
MIE UNIVERSITY;TAKARA BIO INC. |
发明人 |
SHIKU, HIROSHI;IKEDA, HIROAKI;IWAMURA, KOICHI;MINENO, JUNICHI;KATO, IKUNOSHIN |
分类号 |
C12N15/00;A61K31/713;A61K35/12;A61K35/14;A61K48/00;A61P31/00;A61P35/00;A61P37/06;C12N5/0783;C12N5/10;C12N15/09;C12N15/113 |
主分类号 |
C12N15/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|