发明名称 |
Antibodies specific for the protofibril form of beta-amyloid protein |
摘要 |
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human beta-amyloid peptide as compare to low molecular weight forms of beta-amyloid peptide. These isolated antibodies and related pharmaceutically effective compositions may be useful in the therapeutic and/or prophylactic treatment of Alzheimer's disease by effectively blocking the ability of the protofibril form of beta-amyloid peptide to form fibril forms linked with complications associated with Alzheimer's disease. The isolated antibodies of the present invention are also useful in various diagnostic assays and associated kits.
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申请公布号 |
US8470321(B2) |
申请公布日期 |
2013.06.25 |
申请号 |
US20080738955 |
申请日期 |
2008.11.14 |
申请人 |
RAVETCH JEFFREY V.;FUKUYAMA HIDEHIRO;THE ROCKEFELLER UNIVERSITY |
发明人 |
RAVETCH JEFFREY V.;FUKUYAMA HIDEHIRO |
分类号 |
A61K39/395;C07K16/18;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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主权项 |
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地址 |
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