发明名称 |
THERAPEUTIC USES OF MONOCLONAL ANTIBODIES TO THE ANGIOTENSIN-II TYPE-1 RECEPTOR |
摘要 |
The use of monoclonal antibodies to the angiotensin-II type-I receptor is provided for the treatment of cancer and vascular smooth muscle cell proliferation. Specifically, use is provided of a monoclonal antibody or a fragment thereof to a peptide comprising the N-terminal portion of the angiotensin-II type-1 receptor defined by the sequence MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFG in the preparation of a medicament for the treatment of cancer or in the preparation of a medicament for the treatment of vascular smooth muscle (VSM) cell proliferation.
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申请公布号 |
CA2496422(C) |
申请公布日期 |
2013.06.25 |
申请号 |
CA20032496422 |
申请日期 |
2003.08.21 |
申请人 |
QUEEN MARY & WESTFIELD COLLEGE |
发明人 |
VINSON, GAVIN PAUL;PUDDEFOOT, JOHN RICHARD;BARKER, STEWART |
分类号 |
A61K39/395;A61K38/22;A61K39/00;A61K47/48;A61P35/00;C07K7/06;C07K14/72;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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