发明名称 |
Compositions and methods for selective inhibition of VEGF |
摘要 |
Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Such compositions and methods further involve siRNA capable of selectively targeting angiogenic VEGF isoforms while selectively sparing anti-angiogenic isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.
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申请公布号 |
US8470792(B2) |
申请公布日期 |
2013.06.25 |
申请号 |
US20090631078 |
申请日期 |
2009.12.04 |
申请人 |
FROST PHILLIP;DEJNEKA NADINE;BOND OTTRINA S.;SHAMS NAVEED;OPKO PHARMACEUTICALS, LLC. |
发明人 |
FROST PHILLIP;DEJNEKA NADINE;BOND OTTRINA S.;SHAMS NAVEED |
分类号 |
C12N15/11;A61K48/00;C07H21/02;C07H21/04 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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