| 摘要 |
PURPOSE: A method for screening an inhibitor of radiation-induced vascular regeneration loss is provided to suppress reduction of vascular regeneration due to cellular senescence and functional damage to EPCs(endothelial progenitor cells). CONSTITUTION: A method for screening an inhibitor of radiation-induced vascular regeneration loss comprises: a step of contacting a sample with a cell containing p53 gene or protein; and a step of measuring the expression level p53 gene, or protein level or activation of p53 protein. The sample is determined as an inhibitor of radiation-induced vascular regeneration loss when the expression level, protein level, or activation is down-regulated. A composition for suppressing radiation-induced vascular regeneration loss contains a material as an active ingredient, which suppresses expression of p53 gene or reduces activation of p53 protein. A pharmaceutical composition for vascular regeneration contains the inhibitor as an active ingredient. |
