发明名称 |
Composite for thermo-sensitive cell-tissue transplanted scaffold and use thereof |
摘要 |
A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.
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申请公布号 |
US8470597(B2) |
申请公布日期 |
2013.06.25 |
申请号 |
US201113008760 |
申请日期 |
2011.01.18 |
申请人 |
CHIOU SHIH-HWA;PERNG CHERNG-KANG;LIN HAN-TZO;YANG YI-PING;TAIPEI VETERANS GENERAL HOSPITAL |
发明人 |
CHIOU SHIH-HWA;PERNG CHERNG-KANG;LIN HAN-TZO;YANG YI-PING |
分类号 |
A61F13/00;A61K38/17;A61L15/32;C12N5/07;C12N5/0775 |
主分类号 |
A61F13/00 |
代理机构 |
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