发明名称 |
Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes and preparation process and uses of the same |
摘要 |
Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.
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申请公布号 |
US8470522(B2) |
申请公布日期 |
2013.06.25 |
申请号 |
US20060490860 |
申请日期 |
2006.07.20 |
申请人 |
HO MEI-LING;WANG GWO-JAW;CHANG JE-KEN;KAOHSIUNG MEDICAL UNIVERSITY |
发明人 |
HO MEI-LING;WANG GWO-JAW;CHANG JE-KEN |
分类号 |
C12Q1/00;A61K35/32;C12N5/077;C12N15/07 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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