| 摘要 |
A process for the preparation of 1-( hydrazinocarbonyl)-methyl-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2-one involves alkylation of 7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2-one with monobromoacetic acid methyl ether with formation of 1-(methoxycarbonyl)-methyl-1,2-dihydro-3H-1,4-benzodiazepine-2-one, and further interaction thereof with hydrazine hydrate. The alkylation is carried out in chloroform in the presence of potassium carbonate and potassium hydroxide, and phase transfer catalyst. |
