发明名称 |
Humanised antibodies with anti-tumour activity |
摘要 |
The present invention provides humanized antibodies and binding domains thereof with anti-tumor activity. In particular the humanized antibodies have specific binding to and direct killing of human colon tumor cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumor models.
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申请公布号 |
US8470320(B2) |
申请公布日期 |
2013.06.25 |
申请号 |
US20100725192 |
申请日期 |
2010.03.16 |
申请人 |
CLARKE ADAM W.;DOYLE ANTHONY G.;JENNINGS PHILIP A.;KIENZLE NORBERT;POLLARD MATTHEW;CEPHALON AUSTRALIA PTY. LTD. |
发明人 |
CLARKE ADAM W.;DOYLE ANTHONY G.;JENNINGS PHILIP A.;KIENZLE NORBERT;POLLARD MATTHEW |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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