| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a manufacturing method for 4,4-difluoro-3,4-dihydroisoquinolines useful as an agricultural and horticultural bactericide. <P>SOLUTION: The manufacturing method for 4,4-difluoro-3,4-dihydroisoquinolines [for example, 3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline] comprises reacting a carbonyl compound represented by general formula (II) [for example, 3,3-dimethyl-1-quinolin-3-ylisoquinolin-4(3H)-one] with a deoxygenative fluorinating agent such as 2,2-difluoro-1,3-dimethylimidazolidine. <P>COPYRIGHT: (C)2013,JPO&INPIT |
