发明名称 |
Forbindelser til enzyminhibering |
摘要 |
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles. |
申请公布号 |
DK1948678(T3) |
申请公布日期 |
2013.06.24 |
申请号 |
DK20060837164T |
申请日期 |
2006.11.09 |
申请人 |
ONYX THERAPEUTICS, INC. |
发明人 |
ZHOU, HAN-JIE;SUN, CONGCONG, M.;SHENK, KEVIN, D.;LAIDIG, GUY, J. |
分类号 |
C07K5/06;A61K38/55;C07K5/08;C07K5/10 |
主分类号 |
C07K5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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