发明名称 |
FUNCTIONAL ISOTYPE SWITCHING OF CHIMAERIC ANTIBODY CHAINS & CHIMAERIC ANIMALS EXPRESSING DIFFERENT IGH ISOTYPES |
摘要 |
The invention discloses methods for the generation of chimaeric humannon-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. The invention provides non-human mammals that comprise transgenic heavy chain loci (having human variable region gene segments) and that express different IgH isotypes. As well as a range of normal IgH isotypes produced in vivo, aspects of the invention provide normal serum Ig levels and spleen B-cell compartments. |
申请公布号 |
WO2013061098(A3) |
申请公布日期 |
2013.06.20 |
申请号 |
WO2012GB52960 |
申请日期 |
2012.11.30 |
申请人 |
KYMAB LIMITED |
发明人 |
BRADLEY, ALLAN;LEE, E-CHIANG;LIANG, QI;WANG, WEI;LEGENT, ANAIS;KIRBY, IAN;SPENSBERGER, DOMINIK;LIU, HUI;FRIEDRICH, GLENN A |
分类号 |
C12N15/85;A01K67/027 |
主分类号 |
C12N15/85 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|