发明名称 |
POLYPEPTIDES AND ANTIBODIES DERIVED FROM CHRONIC LYMPHOCYTIC LEUKEMIA CELLS AND USES THEREOF |
摘要 |
Cancer treatments use a therapy that: 1) interferes with the interaction between CD200 and its receptor to block immune suppression thereby promoting eradication of the cancer cells; and 2) directly kills the cancer cells either by complement-mediated or antibody-dependent cellular cytotoxicity or by targeting cells using a fusion molecule that includes a CD200-targeting portion. The therapy includes the administration of novel antibodies, functional fragments thereof or fusion molecules containing portions thereof. |
申请公布号 |
US2013158236(A1) |
申请公布日期 |
2013.06.20 |
申请号 |
US201213344195 |
申请日期 |
2012.01.05 |
申请人 |
BOWDISH KATHERINE S.;MCWHIRTER JOHN;KRETZ-ROMMEL ANKE;MARUYAMA TOSHIAKI;ALEXION PHARMACEUTICALS, INC. |
发明人 |
BOWDISH KATHERINE S.;MCWHIRTER JOHN;KRETZ-ROMMEL ANKE;MARUYAMA TOSHIAKI |
分类号 |
C07K16/42;C07K16/30;G01N33/50;G01N33/569;G01N33/574 |
主分类号 |
C07K16/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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