发明名称 |
USE OF POLOXAMINESINES AS INDUCERS OF THE OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL CELLS |
摘要 |
The invention describes for first time the activity of poloxamines as inducers in the differentiation of mesenchymal or progenitor cells. In particular, the invention demonstrates that poloxamines have an osteogenic ability. The invention relates to the use of one or more poloxamines or a pharmaceutical composition comprising same for the preparation of a drug for treting patients with bone defects in general. The invention also relates to a method for inducing the differentiation of mesenchymal or progenitor cells into osteoblasts by bringing said cells into contact with a sterilised aqueous dispersion or solution of one or more poloxamines.
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申请公布号 |
US2013156724(A1) |
申请公布日期 |
2013.06.20 |
申请号 |
US201113704986 |
申请日期 |
2011.05.12 |
申请人 |
ALVAREZ LORENZO CARMEN;REY RICO ANA;SILVA RIVERA TERESA;COUCEIRO FOLLENTE JOSE;CONCHEIRO NINE ANGEL;UNIVERSIDADE DE SANTIAGO DE COMPOSTELA |
发明人 |
ALVAREZ LORENZO CARMEN;REY RICO ANA;SILVA RIVERA TERESA;COUCEIRO FOLLENTE JOSE;CONCHEIRO NINE ANGEL |
分类号 |
A61K31/785;A61K31/133 |
主分类号 |
A61K31/785 |
代理机构 |
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地址 |
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