发明名称 NON-INVASIVE DETECTION OF FETAL GENETIC TRAIT
摘要 <P>PROBLEM TO BE SOLVED: To provide a non-invasive detection method of fetal genetic traits. <P>SOLUTION: This method for performing non-invasive detection of fetal genetic traits includes: subjecting a sample of the blood plasma or serum of a pregnant woman to a size separation so as to obtain a fraction of the sample in which the extracellular DNA present therein substantially consists of DNA comprising 500 base pairs or less; and determining in the sample-fraction the fetal genetic trait(s) to be detected. Such detection can be effected by methods such as PCR (polymerase chain reaction) technology, ligand chain reaction, probe hybridization techniques, or nucleic acid arrays. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2013121359(A) 申请公布日期 2013.06.20
申请号 JP20130019380 申请日期 2013.02.04
申请人 SEQUENOM INC 发明人 HAHN SINUHE;HOLZGREVE WOLFGANG;ZIMMERMANN BERNHARD;LI YING
分类号 C12N15/09;G01N33/53;B01J20/281;C12Q1/68;G01N27/447;G01N30/88;G01N37/00 主分类号 C12N15/09
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