Strongly inactivated and still highly immunogenic vaccine and process of manufacturing thereof

摘要

The present invention relates to an immunogenic product comprising TNFα coupled with KLH, wherein the TNFα is strongly inactivated, which means that the product shows less than 30% of cytolytic activity and/or an inactivation factor of more than 15000, in the conditions of TEST A; an emulsion and a vaccine comprising thereof and methods for preparing said immunogenic product.