发明名称 |
COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION |
摘要 |
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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申请公布号 |
US2013156801(A1) |
申请公布日期 |
2013.06.20 |
申请号 |
US201113327244 |
申请日期 |
2011.12.15 |
申请人 |
BOND VINCENT CRAIG;POWELL MICHAEL;HUANG MING BO;ALI SYED;MOREHOUSE SCHOOL OF MEDICINE |
发明人 |
BOND VINCENT CRAIG;POWELL MICHAEL;HUANG MING BO;ALI SYED |
分类号 |
A61K39/21;A61K38/16;A61K39/00;A61P37/04;C07K14/155;C12N5/071;C12P21/00;G01N33/567 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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