ANTIANGIOGENIC BRASSINOSTEROID COMPOUNDS

摘要

A method of treating a solid tumor in a mammal by inhibiting angiogenesis, comprising administering to the mammal which has a solid tumor selected from the group consisting of breast carcinoma, lung carcinoma, prostate carcinoma, colon carcinoma, ovarian carcinoma, neuroblastoma, central nervous system tumor, multiform glioblastoma and melanoma; a composition comprising brassinosteroids of general formula (I), wherein (I) can be a single or double bond and the configurations of carbon atoms C22 and C23 respectively linked to the substituents HO are S for both carbon atoms and a pharmaceutically acceptable additive.