IDENTIFICATION OF TWO NOVEL BIOMARKERS FOR NIEMANN-PICK DISEASE TYPE C
摘要
This invention provides novel biomarkers for Niemann-Pick disease, type C(NPC). In an exemplary embodiment, the invention provides methods for identifying a subject as having NPC. In embodiments, the methods involve detecting the level of biomarker selected from the group comprising i) galectin-3(LGALS3); ii) cathepsin D(CTSD); iii) LGALS3 and CTSD; and iv) LGALS3 and/or CTSD in combination at least one additional NPC associated biomarker in a sample obtained from the subject. In embodiments, the methods involve comparing the level of biomarker to a reference.
申请公布号
CA2859202(A1)
申请公布日期
2013.06.20
申请号
CA20122859202
申请日期
2012.12.14
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人
PORTER, FORBES D., III;CLUZEAU, CELINE V.M.;WATKINS-CHOW, DAWN E.;WASSIF, CHRISTOPHER A.;PAVAN, WILLIAM J.