发明名称 |
INTRACELLULAR DNA RECEPTOR |
摘要 |
Provided herein are methods of identifying and using compounds that modulate an AIM2 polypeptide-mediated immune response. Further provided herein are methods of treating disease comprising administering to a patient a compound that decreases expression of an AIM2 polypeptide. Further provided herein are methods of providing gene therapy to a patient comprising administering to the patient a gene therapy agent and a compound that decreases expression of an AIM2 polypeptide. In certain embodiments, a compound that decreases expression of an AIM2 polypeptide comprises an siRNA or an shRNA.
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申请公布号 |
US2013158100(A1) |
申请公布日期 |
2013.06.20 |
申请号 |
US201213717204 |
申请日期 |
2012.12.17 |
申请人 |
UNIVERSITY OF MASSACHUSETTS;UNIVERSITY OF MASSACHUSETTS |
发明人 |
LATZ EICKE;HORNUNG VEIT;FITZGERALD KATHERINE A. |
分类号 |
A61K31/7105;A61K31/713;C12N15/85 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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