LIPID NANOPARTICLES CONTAINING COMBINATIONS OF CATIONIC LIPIDS

摘要

The present invention provides lipid nanoparticles etc. containing cationic lipids for delivering drugs containing cationic lipids that make it easy to introduce nucleic acids into cells etc., for example. The cationic lipids are represented by: formula (I) (in the formula: R1 and R2 are the same or different alkenyls etc.; X3 does not exist, or is an alkyl etc.; X1 and X2 are hydrogen atoms, or together form a single bond or an alkylene; Y1 does not exist, or is an anion; L1 is a single bond etc.; and R3 is an alkyl etc.); and formula (II) (in the formula: R4 and R5 are the same or different alkenyls etc.; X4 and X5 are hydrogen atoms, or together form a single bond or an alkylene; X6 does not exist, or is an alkyl etc.; Y2 does not exist or is an anion; a and b are the same or different integers from 0 to 3; L4 is a single bond etc.; R6 is an alkyl etc.; L2 and L3 are -O-, -CO-O- or -O-CO-).