发明名称 |
Variant activin receptor polypeptides and uses thereof |
摘要 |
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided. |
申请公布号 |
AU2008223338(C1) |
申请公布日期 |
2013.06.20 |
申请号 |
AU20080223338 |
申请日期 |
2008.03.06 |
申请人 |
AMGEN INC. |
发明人 |
ZHOU, XIAOLAN;KWAK, KEITH SOO-NYUNG;SUN, JEONGHOON;TAM, LEI-TING TONY;HAN, HQ |
分类号 |
C12N15/12;A61K38/17;C07K14/71;C12N5/10;C12N15/861 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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