发明名称 |
METHOD FOR COMPUTING PHARMACOKINETIC PARAMETERS IN MRI |
摘要 |
The present invention relates to a method of dynamic contrast magnetic resonance imaging aimed to improve characterization of tissue image by improving accuracy of computed pharmacokinetic parameters such as Ktrans (transfer constant across capillary membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing accurate T1 value of a tissue after the contrast is injected based on an intrinsic T10 value the tissue, wherein the intrinsic T10 value is adjusted and/or normalized to improve accuracy of the T1 value computed, which in turn is used for computation of pharmacokinetic parameters at least one of Ktrans.
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申请公布号 |
US2013154638(A1) |
申请公布日期 |
2013.06.20 |
申请号 |
US201213438338 |
申请日期 |
2012.04.03 |
申请人 |
JENA AMARNATH;MEHTA SHASHI BHUSHAN;TANEJA SANGEETA;SARKAR URMI;RAJIV GANDHI CANCER INSTITUTE & RESEARCH CENTRE |
发明人 |
JENA AMARNATH;MEHTA SHASHI BHUSHAN;TANEJA SANGEETA;SARKAR URMI |
分类号 |
G01R33/48 |
主分类号 |
G01R33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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