发明名称 |
SUBSTITUTED-ARYL-(IMIDAZOLE)-METHYL)-PHENYL COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS |
摘要 |
<p>A compound having selective modulating activity at the alpha 2B and or alpha 2C adrenergic receptor subtypes is represented by the general Formula (1): wherein R1-R6 is independently selected from the group consisting of H, C1-6 alkyl, halogen, CH2OH, CH2N(R7)2) CH2CN, C(O)R8, CF3, and aryl; wherein R7 is H or C1-6 alkyl; and R8 is H, C1-6 alkyl or aryl. The compounds of Formula (1) can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.</p> |
申请公布号 |
EP2250153(B1) |
申请公布日期 |
2013.06.19 |
申请号 |
EP20090702950 |
申请日期 |
2009.01.13 |
申请人 |
ALLERGAN, INC. |
发明人 |
SINHA, SANTOSH, C.;HEIDELBAUGH, TODD, M.;BHAT, SMITA, S.;CHOW, KEN |
分类号 |
C07D233/64;A61K31/415;A61P25/00 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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