发明名称 |
PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS |
摘要 |
<p>Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a pH-independent in vitro release profile with NMT 70% in one hour, NMT 85% in 4 hour, and NLT 80% in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome.</p> |
申请公布号 |
EP2603203(A2) |
申请公布日期 |
2013.06.19 |
申请号 |
EP20110749137 |
申请日期 |
2011.08.08 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
CHATTERJI, ASHISH;HUANG, JINGJUN;KOENNINGS, STEPHANIE;LINDENSTRUTH, KAI;SANDHU, HARPREET K.;SHAH, NAVNIT HARGOVINDAS |
分类号 |
A61K9/16;A61K9/20;A61K9/50;A61K31/00 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|