发明名称 |
MODIFIED VIRUS VECTORS AND METHODS OF MAKING AND USING THE SAME |
摘要 |
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors comprising the modified AAV capsid protein. In particular embodiments, the modification comprises a substitution of one or more amino acids at amino acid positions 585 to 590 (inclusive) of the native AAV2 capsid protein sequence or the corresponding positions of other AAV capsid proteins. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo. |
申请公布号 |
EP2396343(A4) |
申请公布日期 |
2013.06.19 |
申请号 |
EP20100741720 |
申请日期 |
2010.02.11 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
SAMULSKI, RICHARD, JUDE;ASOKAN, ARAVIND |
分类号 |
C07K14/075;A61P3/00;A61P9/00;A61P21/00;C12N15/861 |
主分类号 |
C07K14/075 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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