发明名称 |
ENHANCED CYTOTOXICITY OF ANTI-CD74 AND ANTI-HLA-DR ANTIBODIES WITH INTERFERON-GAMMA |
摘要 |
<p>Disclosed herein are methods and compositions comprising interferon-γ(IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γincreases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74+ and/or HLA-DR+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.</p> |
申请公布号 |
EP2523680(A4) |
申请公布日期 |
2013.06.19 |
申请号 |
EP20110732303 |
申请日期 |
2011.01.11 |
申请人 |
CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY;IMMUNOMEDICS, INC. |
发明人 |
BURTON, JACK D.;STEIN, RHONA;GOLDENBERG, DAVID M. |
分类号 |
A61K38/21;A61K39/395 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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