Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells

摘要

A method of diagnosing lung cancer in an individual comprising the steps of:
a) measuring a biological sample comprising nasal epithelial tissue from the individual for the expression of at least 20 gene transcripts from Table 6;
b) comparing the expression of the at least 20 gene transcripts to a control sample of those transcripts from individuals without cancer,
wherein increased expression of the gene transcripts as indicated by a negative score in the last column of Table 6 and/or decreased expression of the gene transcripts as indicated by a positive score in the last column of Table 6 is indicative of the individual having lung cancer.