发明名称 |
HOMOGENIZATION OF A RADIOPHARMACEUTICAL USING SONIFICATION AND/OR ROTOR-STATOR TECHNOLOGY TO PRODUCE A HOMOGENOUS SUSPENSION, EMULSION, MIXTURE OR SOLID SUSPENSION OF IMMISCIBLE INGREDIENTS |
摘要 |
A homogenous dispersion of aqueous droplets of a radiopharmaceutical or radiodiagnostic agent within a non-aqueous medium and method of making the same is provided. The homogenous dispersion is largely free of impurities and constitutes a substantially uniform distribution of sodium thiosulfate and radiopharmaceutical which is stable for a time sufficient to fill and solidify within gel capsules. In making the homogenous dispersion, dry sodium thiosulfate and dry potassium phosphate dibasic anhydrous are uniformly dispersed within non-aqueous, liquid polyethylene glycol.
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申请公布号 |
CA2706111(C) |
申请公布日期 |
2013.06.18 |
申请号 |
CA20082706111 |
申请日期 |
2008.12.03 |
申请人 |
BRACCO IMAGING S.P.A. |
发明人 |
OEHLBERG, PETER J.;SCHRAMM, ERNST |
分类号 |
A61K51/12;A61K9/10;A61M36/14 |
主分类号 |
A61K51/12 |
代理机构 |
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