SCREENING ASSAYS FOR COMPOUNDS FOR USE IN THE TREATMENT OF STRESS-RELATED DISORDERS

摘要

The present invention relates to methods of identifying a compound having a therapeutic activity in the treatment of stress-related disorders. The invention also describes a method of providing a compound having a therapeutic activity in the treatment of stress-related disorders. In a further aspect, the invention relates to an antibody or a binding fragment thereof capable of specifically binding to the histone methyltransferase G9a protein for use as a medicament. The present invention also discloses an inhibitory polynucleotide molecule capable of interfering with the expression of the histone methyltransferase G9a protein and a vector comprising such an inhibitory polynucleotide molecule. The invention in a further aspect also relates to a pharmaceutical composition comprising an antibody or binding fragment thereof or an inhibitory polynucleotide molecule as described herein.