发明名称 |
ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) |
摘要 |
This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), whilst preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast). |
申请公布号 |
WO2013084147(A2) |
申请公布日期 |
2013.06.13 |
申请号 |
WO2012IB56949 |
申请日期 |
2012.12.04 |
申请人 |
NOVARTIS AG |
发明人 |
ELIS, WINFRIED;ETTENBERG, SETH;GARNER, ANDREW PAUL;HAUBST, NICOLE;HUANG, XIZHONG;KUNZ, CHRISTIAN CARSTEN SILVESTER;REISINGER SPRAGUE, ELIZABETH ANNE;SHENG, QING |
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