COMPUTER - IMPLEMENTED SYSTEM FOR SELECTING THERAPY PROFILES OF ELECTRICAL STIMULATION OF CERVICAL VAGUS NERVES FOR TREATMENT OF CHRONIC CARDIAC DYSFUNCTION

摘要

A computer-implemented system and method for selecting therapy profiles (102a-c) of electrical stimulation of cervical vagus nerves (15, 16, 61) for treatment of chronic cardiac dysfunction is provided. An external programmer (40) includes a plurality of therapy profiles (102a-c) stored in memory (29). The therapy profiles (102a-c) include different sets of stimulation parameters (103) that cooperatively define alternating cycles of stimuli application and stimuli inhibition (90) for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand (42) is configured to provide the set of stimulation parameters (103) chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator (12) includes a stimulation therapy lead (13) terminated by helical electrodes (14) and electrically coupled to the neurostimulator (12). The implantable neurostimulator (12) is configured to therapeutically stimulate the cervical vagus nerve (15, 16, 61) through the helical electrodes (14) by triggering bi-directional action potentials as specified by the selected set of stimulation parameters (103).