BORON HETEROCYCLES AS NEW INHIBITORS OF HUMAN NEUTROPHIL ELASTASE

摘要

The invention described herein provides a new family of human neutrophil elastase (HNE) inhibitors. These are boron heterocycles of the general formula shown in (I) and (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined in the specification section as well as their isomers and racemates and their use as HNE inhibitors. The use of these compounds and also of the pharmaceutical compositions and medicaments containing them is useful in treating human HNE related diseases and is therefore applicable in both Pharmaceutical and Medical industries.