发明名称 |
Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases |
摘要 |
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
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申请公布号 |
US2013150294(A1) |
申请公布日期 |
2013.06.13 |
申请号 |
US201213625162 |
申请日期 |
2012.09.24 |
申请人 |
THE UNIVERSITY OF TOLEDO;THE UNIVERSITY OF TOLEDO |
发明人 |
XIE ZI-JIAN;SHAPIRO JOSEPH I.;TIAN JIANG |
分类号 |
C07K14/47;C07K7/08;G01N33/573 |
主分类号 |
C07K14/47 |
代理机构 |
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地址 |
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