| 摘要 |
The present invention relates to a blood coagulation factor Ⅶ derivative, a blood coagulation factor Ⅶa derivative, FacⅦ and FacⅦa conjugates each prepared by linking a polymer capable of extending the blood half-life to the derivative, FacⅦ and Ⅶa complexes each prepared by linking a carrier to the conjugate, genes encoding the FacⅦ and FacⅦa derivatives, expression vectors comprising the genes, transformants introduced with the expression vectors, a method for preparing the FacⅦ and FacⅦa derivatives using the transformants, a method for preparing the FacⅦa conjugate and complex, a FacⅦa complex prepared by the method, a pharmaceutical composition for the prevention or treatment of hemophilia comprising the derivative, conjugate, or complex as an active ingredient, and a pharmaceutical composition for blood coagulation comprising the derivative, conjugate, or complex as an active ingredient. Further, the present invention relates to a method for preventing or treating hemophilia or for promoting blood coagulation, comprising administering to a subject a therapeutically effective amount of the composition. The FacⅦ or FacⅦa derivative of the present invention is able to bind with a carrier capable of improving the blood half-life while maintaining the activity of FacⅦ or FacⅦa, and they can be widely used in the development of effective prophylactic or therapeutic agent for hemophilia. |
